England will be hoping to build on their dramatic late victory against Tunisia and take a commanding stance, along with Belgium, in Group G. Gareth Southgate’s side played some of the best football any team has produced in the tournament in the opening 30 minutes, but hit a wall after Tunisia equalised from a penalty.
England’s team could have been leaked after a photographer snapped the line-up on notes held by the assistant manager Steve Holland. Based on that information, Marcus Rashford may start over Raheem Sterling and Ruben Loftus-Cheek replaces the injured Dele Alli.
Panama, who are ranked 55th in the FIFA world rankings, marked their first ever World Cup appearance with a 3-0 defeat against Belgium. The Panamanians fought hard but fell short of quality in the final third, picking up five yellow cards in the process.
England can secure their place in the knockout stages, but Gareth Southgate is not taking the clash lightly.
"We've seen already the difficulty big countries in terms of rankings have had in breaking down lower-ranked teams," he said. "That's been a theme right the way throughout.
"There's no way there's any complacency in the way we've prepared for the game. The situation in the group is obviously a healthy one for us, but we've got to focus on our performance.
"We want to show people an England team can play in a different way. We've got technically good players, we want them to get on the ball and express themselves and really attack the game like we did the other night."
Where can I watch it?
BBC will show live coverage on BBC One and the BBC Sport website. You can watch all the action live from anywhere in the world with our UK VPN!
What time is it?
Kick off at 13:00 at the Nizhny Novgorod Stadium.
England 2 - 0 Panama
Hopefully there is only one possible outcome in this game. Panama eventually crumbled under the pressure Belgium put on them and they offered very little going forward. If England replicate the standard of play they set in the opening exchanges against Tunisia, there is no reason why they can’t put at least a couple of goals past their opponents.
This will be the first meeting between England and Panama.
England are unbeaten in their last four World Cup games against CONCACAF nations (W2 D2), drawing the last two against USA in 2010 and Costa Rica in 2014. Their only defeat came in 1950 against USA.
Panama will be the 38th different nation England have faced at a World Cup - of the previous 37, they've only lost their first meeting against five; USA and Spain in 1950, Uruguay in 1954, Hungary in 1962 and Italy in 1990.
CONCACAF nations have only won one of their last 10 World Cup meetings against European sides (W1 D3 L6), with Mexico beating Germany in the opening round of matches in this tournament.
In their opening match against Belgium, Panama suffered the biggest defeat in a World Cup debut match (0-3) since Ukraine vs Spain in 2006 (0-4).
England haven't won consecutive games at the World Cup since their opening two games of the 2006 tournament.
Only twice before have England won both of their opening two games to a World Cup campaign (1982 and 2006).
Striker Harry Kane has scored in each of his last four appearances for England, his best ever run for the Three Lions.
In their opening match against Tunisia, Harry Kane became the first England player to score a brace in a World Cup match since Gary Lineker against Cameroon in 1990.
Harry Kane has scored both of England's goals so far at World Cup 2018. The last England player to score more goals in the group stages of a World Cup tournament was Gary Lineker in 1986 (3).